IMMUNOHISTOCHEMICAL APPROACHES TO THE DIAGNOSIS OF EARLY MISCARRIAGE
Abstract
The decidua is a transformed uterine mucosa that provides immune tolerance to the fetus, supports implantation processes and promotes normal pregnancy development. Women with recurrent pregnancy loss (RPL) have abnormalities in the structure and function of the decidua, which can be a key factor in pregnancy loss. Diagnosis of endometrial receptivity in women with recurrent pregnancy loss is an important step in the treatment of this condition. Endometrial receptivity is a key factor in successful embryo implantation, and its impairment can lead to recurrent pregnancy loss (RPL). Diagnosis of endometrial receptivity includes assessment of expression of hormonal receptors (estrogen, progesterone), inflammatory markers (CD20, CD3), cell proliferation (Ki-67) and vascular endothelial factor (VEGF). Modern molecular and immunological methods, including immunohistochemistry, receptivity marker tests, and molecular testing, play a key role in identifying implantation disorders and optimizing treatment.
References
ESHRE Guideline Group on RPL; Bender Atik R., Christiansen O.B. et al. ESHRE guideline: recurrent pregnancy loss: an update in 2022. Hum Reprod Open. 2023;2023(1):hoad002. DOI: 10.1093/hropen/hoad002.
Marini, M.G., et al. Effects of Platelet-Rich Plasma in a Model of Bovine Endometrial Inflammation In Vitro. Reprod Biol Endocrinol, 2016. doi:10.1186/s12958-016-0195-4 (https://doi.org/10.1186/s12958-016-0195-4)
Matrizayeva G.D., Ikhtiyarova G.A. Immunohistochemical features of the endometrium in miscarriage// World Bulletin of Publik Health Vol.17 (2022): WBPH
Van den Boogaard E., Cohn D.M., Korevaar J.C. et al. Number and sequence of preceding miscarriages and maternal age for the prediction of antiphospholipid syndrome in women with recurrent miscarriage. Fertil Steril. 2013;99(1):188–192. DOI: 10.1016/j.fertnstert.2012.09.002.
Friedler, S., et al. Ultrasonography in Endometrial Receptivity Evaluation Post-ART. Hum Reprod Update, 1996. doi:10.1093/humupd/2.4.323 (https://doi.org/10.1093/humupd/2.4.323)
Askarova, Z. Z., Saparbayeva, N. R., Kurbaniyazova, M. Z., & Aliyeva, D. A. (2021). VALUE OF HYSTEROSCOPY AND GENETIC RESEARCH OF WOMEN WITH ABNORMAL UTERINE BLEEDING IN PERIMENOPAUSE. European Journal of Molecular and Clinical Medicine, 8(1), 409-417.
Kurbaniyazova, M. Z., Matrizayeva, G. D., Duschanova, Z. A., & Saparbayeva, N. R. (2019). OVARIAN HYPERSTIMULATION SYNDROME-AS A COMPLICATION OF OVULATION INDUCTION. Central Asian Journal of Pediatrics, 2(2), 123-128.
Askarova, Z. Z., Alieva, D. A., & Kurbaniyazova, M. Z. (2021). IMPROVING EXAMINATION METHODS FOR PATIENTS WITH ABNORMAL UTERINE BLEEDING IN PERIMENOPAUSAL WOMEN. In Euro-Asia Conferences (Vol. 1, No. 1, pp. 148-151).
Askarova, Z. Z., Aliyeva, D. A., & Kurbaniyazova, M. Z. (2023). BREAST CONDITION IN WOMEN WITH ENDOMETRIAL HYPERPLASIA DURING THE PERIMENOPAUSE. World Bulletin of Public Health, 18, 15-17.
Kurbaniyazova, M., & Bekbauliyeva, G. Somatic and hormonal profile of infertile women with chronic anovulation. Turkish Journal of Physiotherapy and Rehabilitation, 32(2).
Zafarjanovna, K. M., Niyetbayevna, B. G., & Atabayevna, D. Z. (2021). Optimization of Ovulation Induction in Clomifene Resistant Patient with Infertility. Biomedical Journal of Scientific & Technical Research, 39(2), 31257-31259.
Курбаниязова, М., & Сапарбаева, П. (2018). Оптимизация индукции овуляции у инфертильных женщин с эндокринным бесплодием. Журнал проблемы биологии и медицины, (4 (104)), 69-71.
Zafarjanovna, K. M., & Niyetbayevna, B. G. International Vritual Conference on Innovative Thoughts, Research ideas and inventions in sciences/Hosted from Newyork, USA January 20th 2021 158-162 page.
ASKAROVA, Z., & KURBANIYAZOVA, M. (2020). The Value of Genetic Research of Women with Abnormal Perimenopausal Bleeding.
Курбаниязова, М. (2018). Профилактика венозных тромбоэмболических осложнений у беременных с варикозным расширением вен малого таза. Журнал проблемы биологии и медицины, (1 (99)), 57-59.
Садуллаев, О., Курбаниязова, М., & Каримова, М. (2017). Корреляционный анализ взаимосвязи нарушений микрофлоры кишечника у детей, больных с диареей проживающих в условиях южного приаралья. Журнал проблемы биологии и медицины, (4 (97)), 190-191.
Садуллаев, О. К., & Курбаниязова, М. З. (2017). ИЗУЧЕНИЕ ПЛАЗМОКОАГУЛИРУЮЩЕЙ СПОСОБНОСТИ МИКРООРГАНИЗМОВ, ВЫДЕЛЕННЫХ ИЗ ФЕКАЛИИ ЗДОРОВЫХ И БОЛЬНЫХ ДЕТЕЙ ДИАРЕЙНЫМИ ЗАБОЛЕВАНИЯМИ ПРОЖИВАЮЩИХ В ЭКОЛОГИЧЕСКИ НЕБЛАГОПРИЯТНЫХ УСЛОВИЯХ ЮЖНОГО ПРИАРАЛЬЯ. Актуальные научные исследования в современном мире, (12-8), 48-50.
Шамсиева, М., Негмаджанов, Б., & Курбаниязова, М. (2014). Оптимизация ведения девочек с вульвитами при диагностированной внутриутробной инфекции у родильниц на современном этапе. Журнал проблемы биологии и медицины, (4, 1 (81)), 97-99.
Zafarjanovna, K. M., & Niyetbayevna, B. G. International Vritual Conference on Innovative Thoughts, Research ideas and inventions in sciences/Hosted from Newyork, USA January 20th 2021 158-162 page.
Askarova, Z. Z., Faizullaeva, N. A., & Kurbaniyazova, M. Z. (2024). IMPORTANCE OF ECHOGRAPHY IN THE DIAGNOSIS OF ADENOMYOSIS. Central Asian Journal of Medical and Natural Science, 5(1), 415-420.
Zafarjanovna, K. M., Niyetbayevna, B. G., Rakhimbayevna, S. N., Tulibayevna, R. D., & Pirzhanova, I. N. (2022). Optimization of treatment for women with infertility. International journal of health sciences, 6(S2), 94-99.
Zafarjanovna, K. M., & Rakhimbayevna, S. N. (2023). Induction of Anovulation in Clomiphene Resistant Women with Endocrine Infertility.
